Octreotide in variceal bleeding.

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Octreotide in variceal bleeding.

Bleeding from oesophageal varices has a high death rate. Injection sclerotherapy is the most appropriate treatment but facilities for this are not always available. Balloon tamponade and vasoactive therapy may be used as stop gap measures. Somatostatin and octreotide are therapeutic candidates for the treatment of variceal bleeding and there are several trials that have compared somatostatin an...

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Octreotide for acute esophageal variceal bleeding: a meta-analysis.

BACKGROUND & AIMS Studies of octreotide have not demonstrated a consistent benefit in efficacy or safety compared with conventional therapies. This study statistically pooled existing trials to evaluate the safety and efficacy of octreotide for esophageal variceal hemorrhage. METHODS We identified randomized trials of octreotide for variceal hemorrhage from computerized databases, scientific ...

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Sclerotherapy with or without octreotide for acute variceal bleeding.

BACKGROUND Sclerotherapy is considered the most effective way to stop bleeding from esophageal varices, but acute variceal bleeding is still associated with a high risk of rebleeding and death. We compared sclerotherapy alone with sclerotherapy and octreotide to control acute variceal bleeding and prevent early rebleeding in patients with cirrhosis. METHODS In a double-blind, prospective tria...

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Variceal bleeding

Approximately 90% of patients with cirrhosis will have developed gastro-oesophageal varices within 10 yr. Oesophageal variceal haemorrhage is a devastating complication of cirrhosis with mortality as high as 25–50%. Therefore, prophylactic measures before the first bleed are crucial. If patients survive a variceal bleed, there is approximately a 70% risk that they will have a further bleed with...

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[Octreotide administration and/or endoscopic treatment in cirrhotic patients with acute variceal bleeding: a multicentric study].

BACKGROUND Acute variceal bleeding in cirrhotic patients is an emergency with a high risk of rebleeding and death. Endoscopic procedures such as sclerotherapy or banding, combined or not with drugs such as octreotide could be considered. AIM To assess the value of octreotide in the control of acute variceal bleeding. PATIENTS AND METHODS Ninety-two patients were randomized into three groups...

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ژورنال

عنوان ژورنال: Gut

سال: 1994

ISSN: 0017-5749

DOI: 10.1136/gut.35.3_suppl.s23